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Perioperative IL-33 is Associated with the Early Stage of Postoperative Neurocognitive Dysfunction After Major Abdominal Surgery

StatusRecruiting
PhaseNot specified
Started
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Record status
This record was last updated November 26, 2024 (before its estimated June 18, 2025 completion). Its status may not reflect the trial's current state.

Record History

  1. Study First Submitted
Perioperative neurocognitive dysfunction(PND) are common complications of major surgery among patients, could be a long-term disease, which sometimes lasts for several years, and it is meaningful to find a biomarker of PND at the early stage.As far as we know, the relationship between IL-33 and PND is not clear yet in the gastrointestinal and hepatic area. Thus, the investigators designed this study to find out the association between IL-33 and occurrence of PND, and determine whether IL-33 could be a biomarker of the early stage of PND.Study population included 150 subjects. Neuropsychological questionnaire were administrated one day before surgery and three days after surgery. And the end of the operation peripheral venous blood was sampled to measure IL-33 inflammatory protein expression in peripheral blood monocytes. Analyze the data and draw conclusions.
Trial Details
NCT Number NCT06704451
Lead Sponsor First Affiliated Hospital of Kunming Medical University
Conditions
(from sponsor)		 Postoperative Neurocognitive Dysfunction, Cognitive Dysfunction, Postoperative Complications, Neuropsychological Tests
Related terms Cognitive Dysfunction, Postoperative Complications
Enrollment 150 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov