Clinical Trial

Nitrous Oxide Neuroimaging

Study acronym: NONI
Completed Early Phase 1
View on ClinicalTrials.gov →
Summary
The purpose of this study is to determine the effects of acute pain on long-term memory and conditioned physiologic responses in the presence and absence of low dose nitrous oxide. Functional magnetic resonance imaging will be used to identify the neural correlates of these phenomena. The study will occur over 2 visits and involves no long-term follow up.
Protocol Amendment History 6 changes
critical Trial completed 2026-08-12
notable Enrollment reduced: 60 -> 37 participants 2026-08-12
notable Primary completion moved earlier: 2026-09-01 -> 2026-06-30 2026-08-12
minor Completion moved earlier: 2026-09-01 -> 2026-06-30 2026-08-12
notable Primary completion pushed: 2026-06-01 -> 2026-09-01 2026-06-05
minor Completion pushed: 2026-06-01 -> 2026-09-01 2026-06-05
Trial Details
NCT Number NCT06702631
Lead Sponsor Keith M Vogt
Collaborators: National Institute of General Medical Sciences (NIGMS)
Conditions Anesthesia, Pain, Amnesia
Enrollment 37 participants
Start Date 2025-01-13
Primary Completion 2026-06-30 (estimated)
Study Completion 2026-06-30 (estimated)
Updated on ClinicalTrials.gov 2026-08-11