Probiotic Supplementation During Pregnancy in Women With High-Risk Pregnancies

Preeclampsia (PE) is a complication during pregnancy characterized by hypertension, organ damage, and inflammation, without an effective treatment. The underlying mechanisms causing the disease also remain partly unknown. In this double-blind placebo-controlled study, the effects of probiotic dietary supplement GutMagnific during pregnancy will be assessed in pregnancies with a high risk of PE as well as low risk. The hypothesis is that probiotic dietary supplement GutMagnific can prevent or reduce the inflammatory response and clinical manifestations associated with PE through counteracting imbalances in the oral and gut microbiome composition.

NCT Number	NCT06700044
Lead Sponsor	Region Skane Collaborators: ImmuneBiotech Medical Sweden AB
Conditions	Preeclampsia, Gut Dysbiosis
Enrollment	150 participants
Start Date	2024-12-10
Primary Completion	2027-12 (estimated)
Study Completion	2027-12 (estimated)
Updated on ClinicalTrials.gov	2024-12-27