How a Single Workout Affects Gut Bugs in Women With Different Fitness Levels and Body Types

This study aims to elucidate the differences in the gut microbiome functional activity and metabolome in adult premenopausal women with distinctive fitness levels and BMIs (with obesity, w/o obesity). The specific aims are as follows: * Aim 1: To examine the effects of acute aerobic exercise at 60-70% heart rate reserve (HRRmax) for 30 minutes bout on changes in the abundance of SCFA-producing bacteria and their functional downstream metabolic activity. * Aim 2: To examine the effects of acute aerobic exercise at 60-70% HRRmax 30-minute bout on changes in GM-released SCFA concentrations in stool and plasmatic metabolome.

NCT Number	NCT06691100
Lead Sponsor	George Washington University
Conditions	Weight Management, Obesity, Exercise, Women, Gut Microbiome, Metabolome, Health, Gut Microbiota
Enrollment	40 participants
Start Date	2024-10-16
Primary Completion	2027-06-01 (estimated)
Study Completion	2027-10-16 (estimated)
Updated on ClinicalTrials.gov	2025-07-24