Acetylcholinesterase Inhibitor in Anorexia Nervosa: Multicenter, Double-Blind, Placebo-Controlled Trial

The goal of this clinical trial is to learn if the daily take of donepezil can treat adult patient suffering from anorexia nervosa. The main question it aims to answer is : do daily donepezil intake permit weight gain and reduction of food restriction rituals ? The treatment is a capsule comprising a drug limiting the degradation of a neurotransmitter called acetylcholine. This treatment has long been used to treat certain cognitive disorders. Researchers will compare two drug dosage and a look-alike capsule that contains no drug to see if the dose has an impact on the effect. Participants will take one capsule per day for three months will have regular hospital visits for cognitive and metabolic tests.

NCT Number	NCT06687993
Lead Sponsor	Centre Hospitalier St Anne Collaborators: Université Paris Cité, Institut National de la Santé Et de la Recherche Médicale, France
Conditions	Anorexia Nervosa Restricting Type
Enrollment	147 participants
Start Date	2024-11
Primary Completion	2030-02 (estimated)
Study Completion	2030-05 (estimated)
Updated on ClinicalTrials.gov	2024-11-14