Clinical Trial

Comparing Analgesic Regimen Effectiveness and Safety for Surgery for Kids Trial

Study acronym: CARES for Kids

Recruiting Phase 4

Summary

This trial is being completed to compare two commonly used options to treat pain after discharge from surgery. Participants that undergo tonsil removal, gallbladder removal, and knee scope will be eligible to enroll. Eligible participants will be randomized to prescription of 1 of 2 groups of medications (Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) plus acetaminophen or low dose opioids with the NSAIDs plus acetaminophen. The key question the study seeks to answer is which option will have the best outcomes and with the fewest side effects?

Protocol Amendment History 3 amendments

This ClinicalTrials.gov record has been amended 3 times since 2024-10-30; most recent amendment 2026-03-02.

Status change: Not Yet Recruiting → Recruiting 2025-01-22

Trial Details

NCT Number	NCT06671002
Lead Sponsor	University of Michigan Collaborators: Patient-Centered Outcomes Research Institute
Conditions	Surgery, Pain, Post Operative
Enrollment	900 participants
Start Date	2025-01-10
Primary Completion	2026-10-16 (estimated)
Study Completion	2027-10-31 (estimated)
Updated on ClinicalTrials.gov	2026-03-04