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Study of Oral Deucrictibant Extended-Release Tablet for Prophylaxis Against Angioedema Attacks in Adolescents and Adults With HAE

Study acronym: CHAPTER-3
StatusActive, Not Recruiting
PhasePhase 3
Started
View on ClinicalTrials.gov ↗
Record status
This record was last updated February 13, 2026 (before its estimated August 2026 completion). Its status may not reflect the trial's current state.

Record History

  1. Trial status: Recruiting to Active, Not Recruiting
    • Site details revised at 56 of 56 sites
    v12
  2. Study sites: 55 to 56v11
  3. Study sites: 52 to 55v10
  4. Study sites: 45 to 52v9
  5. Study sites: 39 to 45v8
Show 6 earlier versionsHide 6 earlier versions
  1. Study sites: 22 to 39v7
  2. Study sites: 10 to 22v6
  3. Study sites: 5 to 10v5
  4. Study sites: 4 to 5v4
  5. Trial status: Not Yet Recruiting to Recruiting
    • Study sites: 0 to 4
    • Start date changed from estimate of Dec 2024 to Dec 1, 2024
    v3
  6. Study Identification, Study Status, Oversight, Contacts/Locationsv2
  1. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
This is a Phase 3, multicenter, randomized, double-blind, placebo-controlled study to evaluate the efficacy and safety of once-daily orally administered deucrictibant extended-release tablet compared to placebo for prophylaxis to prevent angioedema attacks in participants aged ≥ 12 years with hereditary angioedema.
Trial Details
NCT Number NCT06669754
Lead Sponsor Pharvaris Netherlands B.V.
Conditions
(from sponsor)		 Hereditary Angioedema (HAE)
Related terms Angioedemas, Hereditary
Enrollment 81 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov