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Efficacy and Safety of Tenecteplase Bridging Mechanical Thrombectomy for Acute Large Vessel Occlusion Stroke

Study acronym: TNK-LVO
StatusRecruiting
PhasePhase 3
Started
View on ClinicalTrials.gov ↗

Record History

See every version on ClinicalTrials.gov ↗

  1. Eligibility criteria revisedv5
  2. Trial status: Not Yet Recruiting to Recruiting
    • Start date changed from estimate of Dec 2, 2025 to Dec 25, 2025
    • Eligibility criteria expanded, about 26 words
    • Site details revised
    v4
  3. Start date: Feb 2, 2025 to Dec 2, 2025
    • Eligibility criteria expanded, about 43 words
    • Site contact updated
    v3
  4. Start date: Dec 1, 2024 to Feb 2, 2025v2
  5. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
Xuanwu Hospital, Beijing
204 trials monitored
See 3 trials at risk
Stroke
3,531 trials monitored
See 153 trials at risk
A phase III, multicentre, prospective, randomised, open-label, blinded-endpoint clinical trial will evaluate two thrombolytic agents for the treatment of acute large vessel occlusion stroke within 4.5 hours from symptoms onset: intravenous tenecteplase bridging mechanical thrombectomy vs. intravenous alteplase bridging mechanical thrombectomy.
Trial Details
NCT Number NCT06658197
Lead Sponsor Xuanwu Hospital, Beijing
Conditions
(from sponsor)		 Stroke, Ischemic, Stroke, Acute, Thrombosis, Brain, Drug Effect
Related terms Intracranial Thrombosis, Ischemic Stroke, Stroke
Enrollment 850 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov