Peripheral Drivers of Heart Failure Progression - The Prospective PEDAL-HF Study

PEDAL-HF is a registry-based randomized prospective multicenter study. The investigators plan to include 1000 patients who were recently admitted with acute decompensated heart failure at five tertiary heart clinics in Germany. For the randomised part, 750 patients will be randomized to care within a heart failure network or usual care. The primary endpoint of the randomized trial is change in NT-proBNP from baseline to 6 months of follow-up. All patients (randomized or not) will be followed for two years.

NCT Number	NCT06656832
Lead Sponsor	University of Leipzig
Conditions	Heart Failure - NYHA II - IV
Enrollment	1,000 participants
Start Date	2024-11-28
Primary Completion	2028-10-01 (estimated)
Study Completion	2028-12-31 (estimated)
Updated on ClinicalTrials.gov	2026-05-06