Exposure to Organochlorine Pollutants and Impact on Development in the Peripubertal Age in Guadeloupe

In the context of environmental pollution of the French West Indies by chlordecone and questions about health consequences, monitoring at the peripubertal age of children born alive in the TIMOUN cohort is justified in several respects: - existence of an already established mother-child cohort whose live-born children will reach peripubertal ages during the period 2020-2022; - opportunity to verify hypotheses put forward on the basis of toxicological data acquired in laboratory animals and the hormonal characteristics of chlordecone (endocrine disruptor); - strong societal demand for such research to be carried out because of concerns about the sensitivity of children and adolescents to the effects of environmental xenobiotics, in particular on sexual development and the age of puberty; - recommendation of the Scientific Council Chlordecone Inserm - InVS; specific action of the National Plan Chlordecone IV.

NCT Number	NCT06653660
Lead Sponsor	Centre Hospitalier Universitaire de la Guadeloupe Collaborators: Institut National de la Santé Et de la Recherche Médicale, France
Conditions	Prenatal Exposure, Postnatal Exposure
Enrollment	650 participants
Start Date	2022-12-19
Primary Completion	2026-12-19 (estimated)
Study Completion	2026-12-19 (estimated)
Updated on ClinicalTrials.gov	2025-11-17