Pelvis Adaptive Radiotherapy (ART)

Pelvis Adaptive radiotherapy (ART) is a two phase study looking at using adaptive radiotherapy to help reduce toxicity for cancer patients having radiotherapy in the pelvic region. Adaptive radiotherapy is a new technology that provides the ability to account for daily changes in anatomy. Adaptive radiotherapy also provides a foundation for which radiotherapy margins might be safely reduced. Phase 1 of this study is looking to see if a radiation therapist centred adaptive workflow can be implemented. If phase 1 of this study is safe and feasible, the study will proceed to phase 2. Phase 2 of the study looks at using adaptive technology to reduce radiation treatment margins. The primary aim of this study is to see whether margin reduced treatment using adaptive radiotherapy can reduce side effects for patients with cancer in the pelvic area.

NCT Number	NCT06650033
Lead Sponsor	Royal North Shore Hospital Collaborators: Northern Sydney and Central Coast Area Health Service
Conditions	Pelvis Neoplasms
Enrollment	280 participants
Start Date	2025-10-09
Primary Completion	2029-11-30 (estimated)
Study Completion	2031-11-30 (estimated)
Updated on ClinicalTrials.gov	2026-02-05