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REduced-dose Steroid PrOtocol for Childhood Nephrotic SyndromE (RESPONSE)

Study acronym: RESPONSE
StatusActive, Not Recruiting
PhasePhase 3
Started
View on ClinicalTrials.gov ↗

Record History

  1. Trial status: Recruiting to Active, Not Recruiting
    • Primary completion date changed from estimate of Nov 30, 2025 to Feb 16, 2026
    • Study completion date: Nov 30, 2026 to Feb 28, 2027
    • Site details revised
    v3
  2. Trial status: Not Yet Recruiting to Recruitingv2 Show 4 more changesShow less
    • Primary completion date: Oct 31, 2025 to Nov 30, 2025
    • Study completion date: Oct 31, 2026 to Nov 30, 2026
    • Start date changed from estimate of Oct 1, 2024 to Nov 1, 2024
    • Site details revised
  3. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
This is a pilot feasibility study for a proposed full-scale randomized controlled trial to evaluate the effectiveness and safety of a reduced-dose oral prednisone (steroids) regimen to treat childhood steroid-sensitive nephrotic syndrome relapses versus standard-dose prednisone (i.e., usual standard of care). This internal pilot study is a single-center, open-label, randomized controlled trial at The Hospital for Sick Children (Toronto, ON, Canada). The primary objective of this pilot study is to determine the feasibility, safety, and resources needed to conduct the future full-scale randomized controlled trial.
Trial Details
NCT Number NCT06635720
Lead Sponsor The Hospital for Sick Children
Conditions
(from sponsor)		 Nephrotic Syndrome in Children, Nephrotic Syndrome, Minimal Change, Nephrotic Syndrome, Nephrotic Syndrome，Idiopathic
Related terms Glomerulosclerosis, Focal Segmental, Nephrosis, Lipoid, Nephrotic Syndrome
Enrollment 50 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov