PREVENTION OF WORSENING RENAL FUNCTION OF INTRAVENUS ALBUMIN IN HEART FAILURE PATIENTS

Patients hospitalized for acute decompensation of CHF are usually complicated by worsening renal function (WRF) which leads to diuretic resistance and inadequate decongestion as well as poor prognosis. WRF has been attributed to a reflex renal vasoconstriction elicited by intravascular volume depletion during brisk diuresis. The investigators hypothesize that CHF patients with hepatic dysfunction are more prone to WRF due to poor albumin production. This sub-group of CHF patients may benefit more (increased diuretic efficacy and protected against worsening renal function) by the use of IV loop diuretics in combination with an intravascular volume expander such as IV Human Albumin.

NCT Number	NCT06630923
Lead Sponsor	Democritus University of Thrace
Conditions	Diuretics Drug Reactions, Heart Failure; With Decompensation, Albumin; Double
Enrollment	250 participants
Start Date	2023-01-14
Primary Completion	2025-12-01 (estimated)
Study Completion	2026-12-11 (estimated)
Updated on ClinicalTrials.gov	2024-10-08