Study of Low-intensity Focused Ultrasound Effects on Human Memory

This research project is examining the effects of noninvasive brain stimulation on human memory. This study will help to better understand noninvasive brain stimulation techniques that may have the potential to aid in memory dysfunction. Subjects will undergo a magnetic resonance imaging (MRI) and a computed tomography (CT) scan, to take pictures of their brain and skull. They will receive noninvasive brain stimulation using low-intensity focused ultrasound (LIFU) sound waves, to temporarily change brain activity. Their brain signals (MRI or EEG) will be monitored to measure changes in their brain signals. Their heart rate, blood pressure, respiratory rate, eye movement and skin moisture will be monitored as well. They will complete neuropsychological batteries and memory tasks. They will complete questionnaires.

NCT Number	NCT06628193
Lead Sponsor	Virginia Polytechnic Institute and State University
Conditions	Memory
Enrollment	80 participants
Start Date	2024-11-18
Primary Completion	2026-11 (estimated)
Study Completion	2027-05 (estimated)
Updated on ClinicalTrials.gov	2026-03-31