Exercise Activity to Improve Mobility in Patients With CKD and PAD

People affected by chronic kidney disease and concomitant diagnosed peripheral artery disease at intermediate stages, without contraindications to exercise therapy will be invited to participate in the study. Whose providing informed consent, will be randomly assigned to one of two groups: 1. Exercise program receiving two daily 10-minute interval walking sessions at a slow increasing speed. 2. Control group: receiving usual care including optimal medical therapy and nutritional advice. Patients of both groups will be measured at baseline, after the end of the exercise program (6-month) and at follow up (12-month). Outcome measures will include walking ability by the 6-minute walking test (primary outcome) and lower limbs perfusion, body composition, quality of life, laboratory outcomes and long-term hospitalizations.

NCT Number	NCT06621264
Lead Sponsor	University Hospital of Ferrara Collaborators: Universita di Verona, Reggio Calabria
Conditions	Chronic Kidney Disease Stage 3 and 4, Peripheral Artery Disease (PAD)
Enrollment	124 participants
Start Date	2024-10-01
Primary Completion	2025-11-20 (estimated)
Study Completion	2026-12-31 (estimated)
Updated on ClinicalTrials.gov	2025-05-31