Intravenous Acetaminophen After Cardiac Surgery - Definitive Study

Double blind, double dummy trial of the use of IV acetaminophen versus oral acetaminophen for the prevention of delirium after cardiac surgery. The underlying hypothesis is that better pain control and less use of narcotics will lead to a lower incidence of delirium from day 1 to 7 following cardiac surgery. Other important secondary outcomes are the total use of narcotics, ICU and hospital stay, improved cognitive function at 6 months and 1 year post surgery, NSAID use at each centre and associated NSAID complications.

NCT Number	NCT06613178
Lead Sponsor	McGill University Health Centre/Research Institute of the McGill University Health Centre Collaborators: Laval University, University of British Columbia, St. Boniface Hospital, University of Ottawa, Trillium Health Centre, Université de Montréal, Sunnybrook Health Sciences Centre
Conditions	Post Operative Delirium, Post Operative Pain, Post-Op Complication, Post-cardiac Surgery
Enrollment	1,100 participants
Start Date	2024-07-02
Primary Completion	2027-07-01 (estimated)
Study Completion	2027-12-15 (estimated)
Updated on ClinicalTrials.gov	2024-09-25