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Cognitive Training and Neuroplasticity in Mild Cognitive Impairment: COGIT-2 Trial

Study acronym: COGIT-2
StatusRecruiting
PhasePhase 2
Started
View on ClinicalTrials.gov ↗
Trial flagged as At Risk
Primary completion moved at least 12 months later Feb 28, 2029 → Feb 28, 2030
See other at-risk trials from Columbia University

Record History

  1. Primary completion pushed from Feb 28, 2029 to Feb 28, 2030 Completion pushed from Feb 28, 2029 to Aug 31, 2030 · Eligibility criteria shortened, about 32 words · Site contacts updated at 1 of 4 sites · 1 morev9 Show 4 more changesShow less
    • Completion pushed from Feb 28, 2029 to Aug 31, 2030
    • Eligibility criteria shortened, about 32 words
    • Site contacts updated at 1 of 4 sites
    • Study description expanded, about 2 words

    See this version in full on ClinicalTrials.gov ↗

  2. Site contacts updated at 1 of 4 sitesv8
  3. Site contacts updated at 1 of 4 sitesv7
  4. Study sites: 2 to 4 Eligibility criteria shortened, about 24 wordsv6 Show 1 more changeShow less
    • Eligibility criteria shortened, about 24 words

    See this version in full on ClinicalTrials.gov ↗

  5. Phase: Not applicable to Phase 2 Primary completion date: Apr 28, 2029 to Feb 28, 2029 · Completion date: Jun 28, 2029 to Feb 28, 2029v5 Show 2 more changesShow less
    • Primary completion date: Apr 28, 2029 to Feb 28, 2029
    • Completion date: Jun 28, 2029 to Feb 28, 2029
Show 3 earlier versionsHide 3 earlier versions
  1. Trial status: Not Yet Recruiting to Recruiting Study sites: 1 to 2 · Start date changed from estimate of Dec 1, 2024 to Dec 17, 2024v4 Show 2 more changesShow less
    • Study sites: 1 to 2
    • Start date changed from estimate of Dec 1, 2024 to Dec 17, 2024
  2. Start date: Oct 15, 2024 to Dec 1, 2024 Site contact updatedv3 Show 1 more changeShow less
    • Site contact updated
  3. Eligibility criteria expanded, about 19 words Study description shortened, about 3 wordsv2 Show 1 more changeShow less
    • Study description shortened, about 3 words

    See this version in full on ClinicalTrials.gov ↗

  1. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
Effective, clinically meaningful treatments are lacking for patients with mild cognitive impairment (MCI), which is associated with increased risk of transition to dementia. Cognitive training represents an important therapeutic strategy. In a previous study, crossword puzzles were found to be superior to computerized cognitive training on the primary cognitive outcome and function with decreased brain atrophy. Building on these findings, this study will evaluate and compare the impact of high dose crosswords (4 puzzles per week) to low dose crosswords (1 puzzle per week) and a health education control group on the cognition and function of participants.
Trial Details
NCT Number NCT06601933
Lead Sponsor Columbia University
Collaborators: National Institute on Aging (NIA)
Conditions Mild Cognitive Impairment (MCI), Cognitive Training
Enrollment 240 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov