Nitazoxanide for Treatment of Cryptosporidium in Children

The goal of this clinical trial is to learn if nitazoxanide (NTZ) can treat Cryptosporidium infection in children age 6-12 months. The main questions it aims to answer are: * Does NTZ treatment of diarrheal Cryptosporidium infection lower the number of days of diarrhea? * Does NTZ treatment of diarrheal and non-diarrheal Cryptosporidium infection lower the number of days that parasites can be found in the stool? Researchers will compare NTZ to a placebo (a look-alike substance that contains no drug) to see if NTZ works to treat Cryptosporidium. Participants will: * Take NTZ or placebo for 3 days * Receive regular visits from field research assistants * Provide blood and urine samples

NCT Number	NCT06600711
Lead Sponsor	Johns Hopkins Bloomberg School of Public Health Collaborators: National Institute of Allergy and Infectious Diseases (NIAID)
Conditions	Cryptosporidiosis
Enrollment	480 participants
Start Date	2026-09-30
Primary Completion	2028-12 (estimated)
Study Completion	2030-05 (estimated)
Updated on ClinicalTrials.gov	2026-07-07