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Large-coil Parietal Repetitive Transcranial Magnetic Stimulation (rTMS) for Alzheimer Disease (AD)

Study acronym: PROMIS-AD
StatusRecruiting
PhasePhase 1/2
Started2024-10-17
View on ClinicalTrials.gov ↗
The goal of this clinical trial is to learn if using large-coil (or "deep") repetitive transcranial magnetic stimulation (rTMS) targeting the precuneus and surrounding areas is feasible, tolerable, and potentially efficacious for memory in Alzheimer's Disease. Previous work studying rTMS in Alzheimer's is mixed, but recent work studying rTMS of the precuneus is encouraging for both its short-term and long-term effects. The main questions this study aims to answer are: * Is deep rTMS of the precuneus feasible and tolerable in Alzheimer's? * Are there signs of positive brain changes in response to deep rTMS? * Is deep rTMS potentially efficacious for memory in Alzheimer's? Researchers will compare active stimulation to placebo stimulation while obtaining memory testing and measurements of the brain (imaging, scalp electrode measurements, bloodwork) to see if active treatment works to treat Mild Cognitive Impairment (MCI) and mild-to-moderate dementia due to Alzheimer's disease. Participants will: * Engage with memory testing, brain scans, and bloodwork during a comprehensive assessment * Visit the clinic 3 times for 12 consolidated rTMS sessions, followed by 8 once weekly maintenance visits * Be offered a full open-label active treatment course after completing their treatment course if they are initially in the placebo group

Amendment history 2 changes detected by DataLookout

2026-09-05
critical
Primary completion pushed: 2026-10 → 2029-10
2026-09-05
minor
Completion pushed: 2026-10 → 2029-12
Trial Details
NCT Number NCT06597942
Lead Sponsor University of California, Los Angeles
Collaborators: National Institute on Aging (NIA)
Conditions Alzheimer's Disease, Alzheimer Disease, Dementia Alzheimer Type, Mild Alzheimer's Disease, Moderate Alzheimer's Disease, Alzheimer's Disease (AD), Alzheimer's Dementia
Enrollment 54 participants
Start Date 2024-10-17
Primary Completion 2029-10 (estimated)
Study Completion 2029-12 (estimated)
Updated on ClinicalTrials.gov 2026-09-04