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A Study to Obtain Imaging Data in 40 Patients Having Transcatheter Aortic Valve Implantation (TAVI)

Study acronym: CONTINUUM-CT
StatusRecruiting
PhaseNot applicable
Started
View on ClinicalTrials.gov ↗
Trial flagged as At Risk
Primary completion moved at least 3 months later Sep 12, 2026 → Dec 12, 2026
See other at-risk trials from Barts & The London NHS Trust

Record History

See every version on ClinicalTrials.gov ↗

  1. Primary and study completion pushed from Sep 12, 2026 to Dec 12, 2026
  2. Lead sponsor: Barts & The London NHS Trust to Barts & The London NHS Trust
    • Eligibility criteria expanded, about 29 words
    • Secondary endpoints: details revised at 1 of 5 entries
    • Site details revised
  3. Primary and study completion dates: May 26, 2025 to Sep 12, 2026v3
  4. Secondary endpoints revised (5)
    • Eligibility criteria shortened, about 1 word
    v2
  5. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
The aim of this study is to learn if the Computed Tomography scan (CT scan) and heart echo scan TransThoracic Echo scan (TTE or heart echo scan) taken before a Transcatheter Aortic Valve Implantation (TAVI) procedure can be used to predict how the new TAVI valve will perform in the future. To do this the investigators need the usual CT scan before and a new CT scan after the TAVI valve has been put in. At present a CT scan after TAVI procedure is not routinely done. Male and female patients with severe Aortic Stenosis (AS) will be asked to take part. The data from the scans along with routine measures that are taken will be used to assess if there has been any deterioration in the valve at six months. The scan data collected will be used in a computer programme. This programme will be trained to predict TAVI valve performance. The main purpose of this study is to collect the CT scan data before and after the TAVI procedure. The study aims to answer: • Can the investigators obtain additional CT imaging data and other data before and after TAVI to enable the prediction of valve performance? Participants will be asked if they would have another CT scan 6 months after their TAVI procedure, during their routine follow up.
Trial Details
NCT Number NCT06596460
Lead Sponsor Barts & The London NHS Trust
Collaborators: Queen Mary University of London
Conditions
(from sponsor)		 Aortic Stenosis, Severe, Aortic Valve Stenosis
Related terms Aortic Valve Stenosis
Enrollment 40 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov