Transcatheter Aortic Valve Replacement in Severe Low Flow, Low Gradient Aortic Stenosis

LOW-TAVR is a real-world, retrospective and prospective, multicenter Italian registry aimed at evaluating the characteristics and clinical outcomes of patients with severe low flow, low gradient aortic stenosis undergoing transcatheter aortic valve replacement (TAVR) and, in particular: * risk factors * gender differences * comorbidities * pharmacological treatment * TAVR procedural characteristics * periprocedural and in-hospital complications * clinical outcome at 30-day, 1-year, 2-year and 5-year follow-up

NCT Number	NCT06589063
Lead Sponsor	University of Salerno
Conditions	Low Flow, Low Gradient Aortic Stenosis
Enrollment	1,350 participants
Start Date	2024-03-01
Primary Completion	2025-09-01 (estimated)
Study Completion	2037-12-31 (estimated)
Updated on ClinicalTrials.gov	2026-04-07