Clinical Trial

Corticosteroid Effect on Achalasia Variant EGJOO

Active, Not Recruiting Early Phase 1

Summary

EGJOO is a disorder in which the muscles of the esophagus (swallowing tube) do not function in a coordinated fashion so that swallowed material does not pass easily into the stomach. EGJOO often causes symptoms of swallowing difficulties and chest pain. The cause of EGJOO and its optimal treatment are not clear. The investigators research team suspects that EGJOO might be caused by an allergy that involves the esophagus, and that treatment with medications called corticosteroids might improve function of the esophageal muscles. The purpose of this study is to learn how corticosteroid therapy affects the muscles of the esophagus in patients suffering with EGJOO.

Protocol Amendment History 4 amendments

This ClinicalTrials.gov record has been amended 4 times since 2024-09-04; most recent amendment 2026-01-27.

Status change: Recruiting → Active, Not Recruiting 2025-04-25

Trial Details

NCT Number	NCT06588348
Lead Sponsor	Baylor Research Institute
Conditions	Esophagogastric Junction Outflow Obstruction
Enrollment	12 participants
Start Date	2022-07-26
Primary Completion	2026-11 (estimated)
Study Completion	2026-11 (estimated)
Updated on ClinicalTrials.gov	2026-01-28