Clinical Trial

DNA Methylation Trajectories in Aging

Study acronym: EPI-GERAS
Not Yet Recruiting
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Record status
This record was last updated September 3, 2024 (before its estimated June 2025 completion). Its status may not reflect the trial's current state.
Summary
The goal of this observational study is to profile changes in DNA methylation of circulating CD4+ T and CD8+ T cells from healthy young to aged with diagnosis of HFpEF, a particular phenotype of HF which is highly prevalent in aging. The main question it aims to answer is: -Do DNA methylation biomarkers help us to understand the role of inflammation in HFpEF during aging? Our goal is to provide a simple large-scale panel of epigenetic-sensitive biomarkers useful in aged patients with HF in the early natural history of the disease (HFpEF).
Trial Details
NCT Number NCT06582992
Lead Sponsor University of Campania Luigi Vanvitelli
Conditions Heart Failure, Aging
Enrollment 150 participants
Start Date 2024-11
Primary Completion 2025-06 (estimated)
Study Completion 2025-11 (estimated)
Updated on ClinicalTrials.gov 2024-09-03