Evaluation of Biomarkers for Predicting Macronutrient Intake

The goal of this clinical trial is to establish the relationship between macronutrient food intake and the resulting blood and intersticial fluid (ISF )levels of small molecule markers, as well as, validate wearable optical readers and data fusion algorithms to accurately predict individual-specific macronutrient availability in real time. The study involves 1 screening visit of approximately 2 hours and up to 4 study days of approximately 14 hours. Subjects will be asked to arrive in the fasted state on all study days. Fasting prior to screening is not required. On the screening visit, body weight, height, and body composition by Dual-energy X-ray absorptiometry (DXA) will be measured. In addition, habitual dietary intake, physical activity level (PASE), and quality of life (SGRQ-C) will be assessed.

NCT Number	NCT06582381
Lead Sponsor	Texas A&M University Collaborators: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Conditions	Glucose Metabolism, Amino Acid Metabolism
Enrollment	33 participants
Start Date	2023-12-06
Primary Completion	2026-01 (estimated)
Study Completion	2026-12 (estimated)
Updated on ClinicalTrials.gov	2025-07-20