The Effect of ColcHicine on the Incidence of Knee or Hip Replacements

The goal of this clinical trial is to evaluate the effect of treatment with colchicine 0.5mg once daily as compared to placebo in patients with knee or hip osteoarthritis on the incidence of first occurrence of knee or hip replacement. The main question it aims to answer is: Does colchicine lower the number of knee or hip replacements in participants with osteoarthritis? Researchers will compare colchicine to a placebo (a look-alike substance that contains no drug) to see if colchicine works to treat osteoarthritis. Participants will: * take colchicine every day for 3 tot 4.5 years * visit the clinic every year for check-up and tests such as blood samples and x-rays * fill in questionnaires every 3 months

NCT Number	NCT06578182
Lead Sponsor	Sint Maartenskliniek Collaborators: ZonMw: The Netherlands Organisation for Health Research and Development, RSMK, Tiofarma, Dutch Arthritis Foundation Reuma Nederland
Conditions	Osteoarthritis, Knee, Osteoarthritis, Hip
Enrollment	1,410 participants
Start Date	2025-01-01
Primary Completion	2029-03-31 (estimated)
Study Completion	2029-03-31 (estimated)
Updated on ClinicalTrials.gov	2025-02-20