Early TIPS in Patients With Liver Cirrhosis and Ascites

The aim of this clinical trial is to compare the safety and efficacy of transjugular intrahepatic portosystemic shunt (TIPS) implantation with standard treatment (diuretic medications, and if necessary, paracenteses) in patients with liver cirrhosis and development of ascites as the first decompensating event. By creating a shunt between the liver vein and the portal vein, blood is diverted from the portal vein directly into the hepatic vein, which results in a reduction of pressure in the portal vein so that development of ascites is reduced.

NCT Number	NCT06576934
Lead Sponsor	University Hospital Freiburg Collaborators: Jena University Hospital, Johannes Gutenberg University Mainz, University Hospital Muenster, University Hospital, Bonn, University Hospital Munich, Hannover Medical School, University of Leipzig, University Hospital, Aachen, University Hospital Lübeck, Heinrich-Heine University, Duesseldorf
Conditions	Liver Cirrhosis, Ascites Hepatic, Portal Hypertension
Enrollment	134 participants
Start Date	2025-04-01
Primary Completion	2029-01-15 (estimated)
Study Completion	2029-02-15 (estimated)
Updated on ClinicalTrials.gov	2026-05-01