ADSCs Therapy in Patients With CTD-ILD

Connective tissue disease (CTD), an autoimmune and inflammatory disease, usually accompanied by lung interstitial/alveolar inflammation and fibrosis (so called interstitial lung disease, ILD). The prevalence and mortality rate of CTD-ILD increase in recent several years. Although the use of corticosteroids and strong immunosuppressants can improve ILD in some patients with CTD, progressive lung fibrosis which needs lung transplantation and results in respiratory failure, even with mortality is observed. Currently, stem cell therapy is a breakthrough in the treatment of CTD-ILD, and the effective therapy with stem cells for patients with ILD have been reported.

NCT Number	NCT06574581
Lead Sponsor	China Medical University Hospital
Conditions	Connective Tissue Diseases, Interstitial Lung Disease
Enrollment	16 participants
Start Date	2024-08-20
Primary Completion	2027-04-30 (estimated)
Study Completion	2027-11-30 (estimated)
Updated on ClinicalTrials.gov	2026-05-13