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Carbon Monoxide Hyperbaric Oxygen With Steroid Therapy

Study acronym: CODex
StatusNot Yet Recruiting
PhasePhase 1/2
Started
View on ClinicalTrials.gov ↗

Record History

  1. Start date: Jul 2026 to Oct 2026v8
  2. Start date: Jan 2026 to Jul 2026v7
  3. Start date: May 2025 to Jan 2026 Primary completion date: Jan 2027 to Jul 2027v6 Show 1 more changeShow less
    • Primary completion date: Jan 2027 to Jul 2027
  4. Start date: Jan 2025 to May 2025v5
  5. 3 versions Re-verified since Aug 29, 2024, no change to tracked fieldsv2-v4
  6. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
Hyperbaric Oxygen Therapy (HBO) is routine treatment of carbon monoxide (CO) poisoning to prevent delayed neurological sequelae. This study looking to see if neurologic outcomes are improved with the addition of dexamethasone. CO poisoning can initiate a free radical mediated process that can instigate a demyelinating process resulting in long term neurological sequelae in some, but not all patients. In other demyelinating disorders, steroids are a part of first line treatment. HBO is already used for acute CO poisoning, so this pilot study will try to ascertain if the addition of steroids in concert with each hyperbaric oxygen session will yield improved outcomes.
Trial Details
NCT Number NCT06574048
Lead Sponsor University of Nebraska
Conditions Carbon Monoxide Poisoning, Carbon Monoxide Intoxication, Carbon Monoxide Encephalopathy, Carbon Monoxide-induced Parkinsonism
Enrollment 20 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov