Non-invasive Phrenic Nerve Stimulation in ARDS Patient

Reduced diaphragmatic activity during mechanical ventilation can lead to diaphragmatic disuse atrophy, atelectasis, increased lung stress and strain, and hemodynamic impairment. This, in turn, may prolong the duration of mechanical ventilation, make weaning more difficult, and even increase mortality. Synchronizing phrenic nerve stimulation to promote diaphragmatic activity may prevent ventilator-induced lung injury and ventilator-induced diaphragm dysfunction, thereby improving patient outcomes. Surgically implanted phrenic nerve stimulation has been used in certain neurological disorders, but the effects of percutaneous non-invasive synchronized phrenic nerve stimulation in patients with ARDS undergoing mechanical ventilation remain unclear and require further investigation.

NCT Number	NCT06572280
Lead Sponsor	Southeast University, China
Conditions	ARDS, Human, Ventilator-Induced Lung Injury, Diaphragm Injury
Enrollment	10 participants
Start Date	2024-08-01
Primary Completion	2024-12-30 (estimated)
Study Completion	2025-01-30 (estimated)
Updated on ClinicalTrials.gov	2024-08-27