Effects of Negative Pressure Ventilation on Right Ventricular Function in Cardiological Patients

Patients receives induction of general anesthesia for interventional tricuspidal clipping and standard monitoring for this procedure including arterial and central venous line and transesophageal ultrasound. A cuirass for extrathoracal negative pressure ventilation is placed onto the chest but not switched on. During usual positive pressure ventilation a ventilatory, a hemodynamic and a 3D full volume ultrasounddataset of the right and left ventricle is recorded and severity of tricuspidal regurgitation examined. Afterwards negative pressure ventilation is started and positive pressure ventilation reduced as far as possible without reduction of tidal volumes. The same dataset of ventilation, hemodynamics and ultrasound is collected again during negative pressure ventilation. Afterwards the cuirass gets removed, study finished and everything proceeds as during standard procedure.

NCT Number	NCT06572072
Lead Sponsor	Karlsburg Hospital
Conditions	Negative Pressure Ventilation, Right Ventricular Dysfunction, Right Ventricular Failure
Enrollment	30 participants
Start Date	2024-09-01
Primary Completion	2025-09-01 (estimated)
Study Completion	2025-09-01 (estimated)
Updated on ClinicalTrials.gov	2024-08-26