STOP-HSP.Net: a Registry for Hereditary Spastic Paraplegia as an Integration Tool for Future Therapeutic Strategies

Our goal is to create a solid and harmonious disease registry of patient affected by hereditary spastic paraplegia (HSP) that facilitates the collection and management of patients' data over time encouraging the research and the development of future clinical trials. In-depth clinical phenotyping will develop significant clinical outcome measures that can be used in clinical trials and will allow the phenotypic complexity of the disease to be captured with the use of validated clinical scales, biomarkers and so-called patient reported outcomes (PROs).

NCT Number	NCT06572046
Lead Sponsor	IRCCS Fondazione Stella Maris Collaborators: IRCCS Eugenio Medea, Università degli studi di Messina, IRCCS Istituto delle Scienze Neurologiche di Bologna, Catholic University of the Sacred Heart, CINECA, Fondazione Telethon
Conditions	Hereditary Spastic Paraplegia
Enrollment	500 participants
Start Date	2024-01-24
Primary Completion	2027-12-31 (estimated)
Study Completion	2029-12-31 (estimated)
Updated on ClinicalTrials.gov	2026-03-27