Clinical Trial

Harnessing Macrophage Lysosomal Lipid Metabolism in Obesity (ATM)

Study acronym: ATM
Recruiting
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Summary
The goal of this study is to evaluate the role of transcription factor EB (TFEB) in adipose (fat) tissue macrophages (ATM) in regulating adipose tissue and systemic metabolic function in obesity. The investigators will assess the differences in ATM lipid metabolism in people with metabolically abnormal obesity and lean individuals. Both groups will have: * screening visit * imaging (body composition testing - dual-energy x-ray absorptiometry (DEXA) scans, magnetic resonance imaging \[MRI\] and magnetic resonance spectroscopy \[MRS\] scans) * Overnight visit with intravenous infusion (IV), muscle, and fat tissue biopsies
Protocol Amendment History 1 amendment
This ClinicalTrials.gov record has been amended once since 2024-08-22.
Trial Details
NCT Number NCT06571474
Lead Sponsor Bettina Mittendorfer
Collaborators: National Institutes of Health (NIH), National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), Washington University School of Medicine
Conditions Obesity, Non-Alcoholic Fatty Liver Disease, Diabetes Mellitus, Type 2, Healthy
Enrollment 60 participants
Start Date 2024-08-01
Primary Completion 2028-03 (estimated)
Study Completion 2028-03 (estimated)
Updated on ClinicalTrials.gov 2026-08-06