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Fatigue Alleviation Through Neuromodulating Therapy in Multiple Sclerosis

Study acronym: FANTiMS
StatusRecruiting
PhaseNot applicable
Started
View on ClinicalTrials.gov ↗
Trial flagged as At Risk
Primary completion moved at least 4 months later Sep 1, 2026 → Jan 21, 2027
See other at-risk trials from Danish Research Centre for Magnetic Resonance

Record History

See every version on ClinicalTrials.gov ↗

  1. Primary completion pushed from Sep 1, 2026 to Jan 21, 2027 Show 4 more changesShow less
    • Study completion pushed from Nov 1, 2026 to Feb 21, 2027
    • Eligibility criteria expanded, about 16 words
    • Secondary endpoints: details revised at 5 of 5 entries
    • Publications: details revised at 1 of 1 entry
  2. Primary completion date: Jan 1, 2026 to Sep 1, 2026
    • Study completion date: Feb 1, 2026 to Nov 1, 2026
    • Eligibility criteria expanded, about 17 words
    v3
  3. Trial status: Not Yet Recruiting to Recruiting
    • Study sites: 0 to 1
    v2
  4. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
The goal of this clinical trial is to learn if repetitive Transcranial Magnetic Stimulation (rTMS) of the left premotor cortex can lessen fatigue in patients with Multiple Sclerosis, and if this is a feasible intervention. It will also give further information on fatigue in Multiple Sclerosis. The main questions it aims to answer is: * Does premotor rTMS decrease fatigue symptoms in patients with Multiple Sclerosis? * Is the change in fatigue reflected in an altered balance between brain excitation and inhibition in the targeted premotor cortex? Researchers will compare real rTMS with sham rTMS (which does not stimulate with a magnetic field), to see if real rTMS works to alleviate fatigue. Participants will: * Receive real or sham rTMS for 30 minutes, 5 days in a row * Visit the clinic before and 6 days after for baseline and follow-up * Fill out on-line questionnaires 1 day and 4 weeks after the end of intervention * Undergo a total of 3 brain scans (Magnetic Resonance Imaging at ultra-high field), at baseline, end of intervention, and follow-up * Undergo lab neurophysiological measurements before and after the first intervention session * Keep a fatigue diary and wear an activity tracker in the period before and after the intervention
Trial Details
NCT Number NCT06569550
Lead Sponsor Danish Research Centre for Magnetic Resonance
Collaborators: Danish Multiple Sclerosis Center, Scleroseforeningen, Independent Research Fund Denmark
Conditions
(from sponsor)		 Multiple Sclerosis, Relapsing-Remitting, Fatigue
Related terms Fatigue, Multiple Sclerosis, Relapsing-Remitting
Enrollment 60 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov