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Prevention of Infections in Cardiac Surgery (PICS): a Cluster-randomized Factorial Cross-over Trial

Study acronym: PICS
StatusNot Yet Recruiting
PhasePhase 4
Started
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Record History

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  1. Start date: Aug 1, 2025 to Mar 1, 2026v5
  2. Start date: May 1, 2025 to Aug 1, 2025v4
  3. Start date: Dec 31, 2024 to May 1, 2025v3
  4. Secondary endpoints revised (6)v2
  5. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
The goal of this pragmatic, multi-centre factorial cluster randomized cross-over trial is to assess the efficacy of a combination of cefazolin plus vancomycin compared to cefazolin monotherapy, as well as a comparison of short versus long-term prophylaxis with four study arms: 1) cefazolin short-term, 2) cefazolin long-term, 3) cefazolin plus vancomycin short-term and 4) cefazolin plus vancomycin long-term.
Trial Details
NCT Number NCT06567808
Lead Sponsor Hamilton Health Sciences Corporation
Collaborators: Canadian Institutes of Health Research (CIHR)
Conditions
(from sponsor)		 Infection, Surgical Site
Related terms Surgical Wound Infection
Enrollment 38,000 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov