Clinical Trial

Prevention of Infections in Cardiac Surgery (PICS): a Cluster-randomized Factorial Cross-over Trial

Study acronym: PICS
Not Yet Recruiting Phase 4
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Summary
The goal of this pragmatic, multi-centre factorial cluster randomized cross-over trial is to assess the efficacy of a combination of cefazolin plus vancomycin compared to cefazolin monotherapy, as well as a comparison of short versus long-term prophylaxis with four study arms: 1) cefazolin short-term, 2) cefazolin long-term, 3) cefazolin plus vancomycin short-term and 4) cefazolin plus vancomycin long-term.
Protocol Amendment History 4 amendments
This ClinicalTrials.gov record has been amended 4 times since 2024-08-20; most recent amendment 2026-03-10.
Trial Details
NCT Number NCT06567808
Lead Sponsor Hamilton Health Sciences Corporation
Collaborators: Canadian Institutes of Health Research (CIHR)
Conditions Infection, Surgical Site
Enrollment 38,000 participants
Start Date 2026-03-01
Primary Completion 2028-04-30 (estimated)
Study Completion 2028-07-30 (estimated)
Updated on ClinicalTrials.gov 2026-03-12