Leucine Supplementation Strategies to Enhance Muscle Anabolic Responses in Older Age

Sarcopenia describes the progressive decline of muscle mass and strength with advancing age and is associated with increased frailty and morbidity, however we do not currently have an effective treatment. Protein feeding and exercise is known to increase muscle mass, but aged muscle shows a lower response to these stimuli leading to muscle loss over time. We do know that ingesting leucine, a building block of protein, can overcome this reduced response to protein feeding and exercise leading to increased muscle mass in older people. However, we do not understand when the optimum time to ingest leucine is to maximise muscle mass after exercise in older people. In this study we will examine the effect of feeding leucine after exercise either with a meal or between meals.

NCT Number	NCT06567665
Lead Sponsor	University of Nottingham
Conditions	Muscle Protein Synthesis
Enrollment	10 participants
Start Date	2024-08-05
Primary Completion	2026-08-05 (estimated)
Study Completion	2026-08-05 (estimated)
Updated on ClinicalTrials.gov	2026-05-04