The Effects of Insomnia Treatment on Overnight Regulation of Emotional Memories and Risk for Mental Disorders

This project aims to elucidate whether CBCTi changes symptom severity or even remission of anxiety disorders as compared with a delayed-start control group. The investigators will use a delayed-start randomized controlled trial in a cohort of individuals with anxiety and insomnia (N=98) to compare the effects of an online therapist-guided cognitive behavioural and circadian therapy for insomnia versus control on overnight emotion regulation and mental health outcomes. The project will involve at-home assessments and in-lab visits. At-home assessment involves recording sleep and circadian rhythm measures with wearables and daily diaries. Participants will be invited to perform two sleep studies and neuroimaging sessions to investigate the effects of CBCTi on neuroimaging and psychophysiological markers of overnight regulation of emotional distress.

NCT Number	NCT06567210
Lead Sponsor	Woolcock Institute of Medical Research Collaborators: Macquarie University, Australia
Conditions	Insomnia Chronic, Anxiety
Enrollment	98 participants
Start Date	2026-01-06
Primary Completion	2029-06 (estimated)
Study Completion	2030-06 (estimated)
Updated on ClinicalTrials.gov	2025-11-26