DPA-714 and FDG PET/MRI in Depression

Depression, a common psychological disorder, is characterized by persistent low mood, loss of interest, and anhedonia, leading to significant dysfunctions and a high suicide risk. Its pathogenesis remains challenging, with recent focus on neuroinflammation-a chronic immune response in the central nervous system-as a potential contributor. PET imaging, using tracers like 18F-FDG and \[18F\]DPA-714, can visualize metabolic and neuroinflammatory changes. Combining these two tracers can explore the correlation between neuroinflammation and glucose metabolism in depression, further elucidating its possible mechanisms. We hypothesize that microglial activation in depression, especially in major gray matter regions of interest (prefrontal cortex, anterior cingulate cortex, and insula) and 12 additional regions and subregions, will show higher TSPO levels and increased glucose metabolism compared to the control group.

NCT Number	NCT06565936
Lead Sponsor	The First Affiliated Hospital of Dalian Medical University
Conditions	Depression
Enrollment	70 participants
Start Date	2024-08-23
Primary Completion	2026-08 (estimated)
Study Completion	2026-12 (estimated)
Updated on ClinicalTrials.gov	2024-11-12