Individualized Tumor-Informed CtDNA Analysis for Monitoring Postoperative Recurrence in ESCC (NEOCRTEC2401)

The goal of this observational study or is to explore the correlation between dynamic changes in postoperative circulating tumor DNA (ctDNA) and recurrence risk using a novel, tumor-informed ctDNA detection technique, thus laying the foundation for further promoting ctDNA detection to guide postoperative adjuvant therapy decisions. This study focuses on patients with esophageal squamous cell carcinoma who did not achieve pCR following neoadjuvant therapy combined with surgical resection. The main question it aims to answer is: Is there a correlation between postoperative ctDNA changes and tumor recurrence? Participants will be asked to undergo postoperative ctDNA detection.

NCT Number	NCT06561178
Lead Sponsor	Sun Yat-Sen University Cancer Center
Conditions	Esophageal Squamous Cell Carcinoma
Enrollment	50 participants
Start Date	2024-08-26
Primary Completion	2027-12-30 (estimated)
Study Completion	2028-06-01 (estimated)
Updated on ClinicalTrials.gov	2024-08-29