Clinical Trial

Single-Cell Sequencing Analysis of Radiation Pneumonitis Signals In Patients Treated For Cancer With Radiotherapy

Study acronym: SPITFIRE
Recruiting
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Summary
Patients with signs of radiation induced lung inflammation, who are referred for a clinical bronchoscopy for investigation, will have a sample sent for single cell sequencing. This is a novel technique which allows for identification of which cells are present and what they are doing. This hopes to better understand radiation pneumonitis, a dose-limiting toxicity in cancer treatment which can be highly morbid and even fatal.
Protocol Amendment History 4 amendments
This ClinicalTrials.gov record has been amended 4 times since 2024-08-13; most recent amendment 2026-01-08.
Status change: Not Yet Recruiting → Recruiting 2025-02-04
Trial Details
NCT Number NCT06557343
Lead Sponsor NHS Lothian
Conditions Radiation Pneumonitis
Enrollment 5 participants
Start Date 2024-10-25
Primary Completion 2026-10 (estimated)
Study Completion 2026-12 (estimated)
Updated on ClinicalTrials.gov 2026-01-09