Cardiotoxicity of Carbon Monoxide in Patients Treated With Hyperbaric Oxygen Therapy

Carbon monoxide poisoning is a frequent domestic accident and the leading cause of death from unintentionnal poisoning. Its toxicity is based on the CO binding to hemoglobin and myoglobin, inhibition of mitochondrial cytochrome oxidase, resulting in tissue hypoxia and reduced adenosine triphosphate synthesis and ischemia-reperfusion injury. This study aims to investigate the early and late cardiologic effects of CO in patients treated with hyperbaric oxygen (HBOT) for CO poisoning

NCT Number	NCT06549621
Lead Sponsor	University Hospital, Brest
Conditions	Carbon Monoxide Poisoning
Enrollment	66 participants
Start Date	2022-07-25
Primary Completion	2022-10-25 (estimated)
Study Completion	2024-10-25 (estimated)
Updated on ClinicalTrials.gov	2024-08-12