Prostate Adaptive Radiation Therapy

Prostate ART is a two phase study looking at using adaptive radiotherapy to help reduce toxicity for prostate cancer patients. Adaptive radiotherapy is a new technology that provides the ability to account for daily changes in anatomy. Adaptive radiotherapy also provides a foundation for which radiotherapy margins might be safely reduced. Phase 1 of this study is looking to see if a radiation therapist centred adaptive workflow can be implemented. If phase 1 of this study is safe and feasible, the study will proceed to phase 2. Part 2 of the study looks at using adaptive technology to reduce radiation treatment margins. The primary aim of this study is to see whether margin reduced treatment using adaptive radiotherapy can reduce side effects for prostate cancer patients.

NCT Number	NCT06547398
Lead Sponsor	Royal North Shore Hospital Collaborators: Northern Sydney and Central Coast Area Health Service
Conditions	Prostatic Neoplasms
Enrollment	130 participants
Start Date	2025-10-01
Primary Completion	2029-10-31 (estimated)
Study Completion	2031-10-31 (estimated)
Updated on ClinicalTrials.gov	2026-02-05