Gut Microbiota-dependent Health Impacts of Haskap Berries

Polyphenol-rich Haskap berries (Haskap) have untapped therapeutic potential to improve human health, and agricultural producers in northern U.S. states are poised to increase production if consumer demand increases. A critical knowledge gap is that little is known about the interactions between gut microbes and Haskap polyphenols to produce bioactive metabolites linked to downstream health impacts. Additionally, little is known about which Haskap varieties and harvest timing yield the greatest bioactive potential. This study aims to address these gaps by investigating the interaction of bioactive components in Haskap with gut microbiota and the resultant gut and serum metabolites, inflammation, and metabolic health, and then couple this with analysis of berries from different Haskap varieties and harvest times.

NCT Number	NCT06546020
Lead Sponsor	Montana State University Collaborators: Montana State Agricultural Experiment Station
Conditions	Metabolic Disease, Inflammation, Microbial Colonization
Enrollment	120 participants
Start Date	2025-02-26
Primary Completion	2027-05 (estimated)
Study Completion	2028-05 (estimated)
Updated on ClinicalTrials.gov	2025-04-02