SUPPLEMENTATION WITH BETA GLUCAN AND ADAPTATIVE RESPONSE.

Abstract: Studies demonstrate that the use of nutritional supplements containing beta-glucans stimulates the immune system, modulates inflammatory activity, and promotes so-called immune training. Beta-glucans are prebiotics that stimulate the growth and activity of gastrointestinal microbiota and inhibit pathogen growth. Nutritional intervention is crucial for patients\' positive evolution, and providing a supplement with highly bioavailable nutrients can make a difference in their nutritional, metabolic, and immune status. Therefore, the study aims to verify the effectiveness of the innate and adaptive immune response to a nutritionally balanced fermented food, containing oral or enteral beta-glucans, in patients treated at 3 Emergency Care Units in São José do Rio Preto, São Paulo, Brazil. This is a prospective randomized study with a characteristic design involving patients treated in the medical wards of 3 Emergency Care Unit. The following assessments will be conducted: Global Subjective Assessment for adults and Mini Nutritional Assessment for the elderly, Sociodemographic, and Laboratory Evaluation.

NCT Number	NCT06545149
Lead Sponsor	Federal University of São Paulo Collaborators: Kaiser Clinic and Hospital
Conditions	Clinical Course
Enrollment	44 participants
Start Date	2024-10
Primary Completion	2025-10 (estimated)
Study Completion	2025-12 (estimated)
Updated on ClinicalTrials.gov	2024-08-09