Transcutaneous Auricular Vagus Nerve Stimulation in Dry Eye Disease With Meibomian Gland Dysfunction

Objective: To evaluate the effect of transcutaneous auricular vagus nerve stimulation (taVNS) for the patients with dry eye disease with meibomian gland dysfunction. Methods: We enrolled 270 patients at Beijing Tongren Hospital. All treatments were self-administered by the patients at home after training at the hospital. Patients completed questionnaires at baseline, 1 month, 3 months, and 6 months. OSDI score, TBUT, OPAS, NPSI-eye, and Schirmer I expressibility and secretion score to evaluate the therapeutic effects. A difference of P \< 0.05 was considered statistically significant.

NCT Number	NCT06544447
Lead Sponsor	Beijing Tongren Hospital
Conditions	Dry Eye
Enrollment	135 participants
Start Date	2021-06-01
Primary Completion	2024-10-01 (estimated)
Study Completion	2024-10-01 (estimated)
Updated on ClinicalTrials.gov	2024-08-09