The Relationship Between Serum Chemokine Ligand 21 (CCL-21) Level and Disease Activity

Rheumatoid arthritis (RA) is a chronic systemic disease characterized by the development of new capillaries involved in the infiltration of inflammatory cells causing synovial hyperplasia and progressive destruction of cartilage and bone.Osteoarthritis (OA) is a degenerative joint disease that involves articular cartilage and other intra-articular structures.Although the pathological mechanisms involved in OA and RA are different, the onset and progression of both diseases are associated with inflammation, immune mechanisms and metabolic factors.C-C Motif Chemokine Ligand 21 (CCL21) is a CCR7-binding chemokine that plays an important role by modulating the circulation of T cells and dendritic cells in lymphoid and peripheral organs (9). Ligation of CCL21 in RA fibroblasts and macrophages induced the production of proangiogenic factors such as VEGF, Ang-1, and IL-8, suggesting that CCL21 plays an indirect role in RA angiogenesis.The aim of our study is to evaluate the serum levels of CCL21 in RA and OA patients by comparing them with healthy controls. In addition, the aim is to examine the correlation of serum CCL21 with disease degree/severity in both diseases and to determine whether it can be a biomarker of the disease state.

NCT Number	NCT06540573
Lead Sponsor	Gaziosmanpasa Research and Education Hospital
Conditions	Rheumatoid Arthritis, Osteoarthritis
Enrollment	60 participants
Start Date	2024-08-12
Primary Completion	2024-11-15 (estimated)
Study Completion	2024-11-30 (estimated)
Updated on ClinicalTrials.gov	2024-08-06