Developing a Whole-body MRI and Diffusion-weighted Imaging State-of-the-art Protocol: a Pilot Study

Whole-body magnetic resonance imaging (WB-MRI) is a non-ionizing imaging method that can provide WB coverage using essential imaging contrasts with the possibility to include sequences focusing in specific body-regions as needed per case. WB-MRI is increasingly being used for the management of cancer patients, especially metastatic ones. An integral part of WB-MRI is becoming whole-body diffusion-weighted MRI (WB-DWI) which is a non-invasive tool used for staging and response evaluation in oncologic practice. WB-DWI is an inherently noisy technique, resulting in it accounting for more than 50% of the acquisition time of conventional whole-body MRI studies with overall duration at least 1-hour. Reducing acquisition times, without compromising image or diagnostic quality would facilitate the wider adoption of clinical WBDWI, reducing costs, and improving the patient experience

NCT Number	NCT06533189
Lead Sponsor	Fondazione Policlinico Universitario Agostino Gemelli IRCCS Collaborators: GE Healthcare
Conditions	Whole Body Imaging, Cancer, Genetic Predisposition
Enrollment	120 participants
Start Date	2024-09-01
Primary Completion	2025-12-31 (estimated)
Study Completion	2026-02-28 (estimated)
Updated on ClinicalTrials.gov	2024-08-01