The Effect of Therapeutic Exercise on Cartilage Morphology and Physical Function for Individuals at High Risk of Knee Osteoarthritis

This randomized controlled trial aims to evaluate the efficacy of progressive resistance exercises (PRE) versus aerobic exercises on cartilage morphology and physical function in patients with degenerative meniscus tears. 45 participants, aged 35-55, will be randomly assigned to one of three groups: PRE, aerobic exercise, or control (standard of care physical and medical therapy). The study will utilize MRI T2 mapping to assess changes in cartilage composition and patient-reported and performance-based measures to evaluate clinical outcomes. This pilot study will also determine the feasibility and issues related to recruitment and retention for a larger trial.

NCT Number	NCT06532851
Lead Sponsor	Jordan University of Science and Technology
Conditions	Meniscus Tear
Enrollment	50 participants
Start Date	2023-06-01
Primary Completion	2030-12-01 (estimated)
Study Completion	2031-03-01 (estimated)
Updated on ClinicalTrials.gov	2026-05-12