Impact of Exercise Training on Ischemia With Non-Obstructive Coronary Arteries (INOCA): The ExINOCA Study

The purpose of the study is to identify causes of chest pain in patients experiencing chest pain with no signs of narrowing of the coronary arteries of the heart, and to investigate whether physical exercise can improve coronary microvascular function. Hypotheses: The first hypothesis is that in INOCA, with reduced function of microvasculature of the heart, this reduced function also occurs in other organs of the body. The second hypothesis is that regular physical activity (aerobic exercise training) can improve coronary microvascular function, reduce symptoms, and that there is a parallel improvement in vascular function in other organs of the body.

NCT Number	NCT06529848
Lead Sponsor	Bispebjerg Hospital Collaborators: University of Copenhagen
Conditions	Coronary Microvascular Disease, CMD
Enrollment	100 participants
Start Date	2024-11-01
Primary Completion	2027-10-30 (estimated)
Study Completion	2028-05-15 (estimated)
Updated on ClinicalTrials.gov	2025-02-21