Effect of Coffee and Agave Inulin-based Beverage on Appetite in Adults With Obesity.

Nutritional treatment is key in managing obesity; however, the lack of fullness or satiety signals may affect adherence to this treatment. Coffee and inulin consumption, separately, have been shown to increase satiety and GLP-1 concentrations and reduce appetite and energy intake, but they have not been evaluated together. It is necessary to obtain scientific evidence contributing to recommendations for controlling appetite in an obesity context. Therefore, this study aims to analyze the use of coffee and agave inulin-based beverage consumption on appetite sensations, dietary intake, and ghrelin, GLP-1, and PYY concentrations in adults with obesity. For that purpose, a double-blind, randomized crossover clinical trial was designed to evaluate the effect of daily consumption, during two weeks, of a coffee and inulin-based beverage compared to a control beverage. Appetite sensations will be analyzed with visual analogue scales, dietary intake with a 3-day self-reporting of food intake, and appetite hormones with ELISA assays. The measurements will be performed in 6 scheduled sessions. In each session, fasting and postprandial appetite variables will be evaluated.

NCT Number	NCT06527209
Lead Sponsor	University of Guadalajara Collaborators: Hospital Civil de Guadalajara
Conditions	Obesity
Enrollment	30 participants
Start Date	2024-06-24
Primary Completion	2025-07-31 (estimated)
Study Completion	2025-07-31 (estimated)
Updated on ClinicalTrials.gov	2024-07-30