Relationships Between Tenascin C, Smoking and Periodontal Status

The goal of this observational study is to determine if there is a relationship between different periodontal conditions (gingival healthy, stage 2 grade B, stage 2 grade C, stage 3 grade B, stage 3 grade C) and the levels of tenascin C, IL-1 beta, IL-4, and IL-6 in saliva samples from smokers and non-smokers. The main questions it aims to answer are: Is there a difference in the levels of tenascin C, IL-1 beta, IL-4, and IL-6 between smokers and non-smokers with different periodontal conditions? Do these biomarkers correlate with the severity and grade of periodontal disease? Researchers will compare the saliva samples from smokers and non-smokers across the different periodontal conditions to see if there are significant differences in the biomarker levels. Participants will: Provide saliva samples. Be categorized based on their smoking status and periodontal condition.

NCT Number	NCT06523205
Lead Sponsor	Necmettin Erbakan University
Conditions	Periodontitis, Smoking, Periodontal Diseases
Enrollment	100 participants
Start Date	2024-08-01
Primary Completion	2024-09-01 (estimated)
Study Completion	2024-09-15 (estimated)
Updated on ClinicalTrials.gov	2024-07-26